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OUR FOCUS AREAS

Infectious Diseases

Along with the expansion of the global economy and the increased transnational movement of both people and goods, the threat of a pandemic of a serious infectious disease, involving new or recurring pathogens or multidrug-resistant bacteria, is looming and spreading globally at an alarming speed. To bring smiles back to those who suffer from infectious diseases, we at Shionogi continue to make efforts toward the discovery and development of therapeutic and prophylactic drugs for bacterial, fungal, and viral infections based on our excellent drug development and medical research capabilities. We also participate in the Global Health Innovative Technology Fund (GHIT), which is part of a public-private partnership commitment, conducting research on drugs for multidrug-resistant tuberculosis or neglected tropical diseases.

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Our latest findings

Trojan Horse: The discovery of a new antibiotic, Cefiderocol (S-649266)

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We developed Cefiderocol (S-649266), a new siderophore cephalosporin having two distinct properties: (1) quick transmission through the strong outer membrane barrier via an active iron uptake pathway; and (2) high stability against carbabenemase which is capable of cleaving β-lactam antibiotics, including carbapenem derivatives.

FIC* Leading the World: Development of Baloxavir, a New Anti-Influenza Agent

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Shionogi's Infectious Disease Study Group led by Mr. Takao Shishido worked on the development of new anti-influenza agents with a completely different mechanism of action from that of conventional drugs and found S-033188 (Baloxavir Marboxil).
*FIC: First-in-Class (Especially novelty/effectiveness is high, original medicinal products which greatly change traditional treatment).

Neuroscience

Patients with psychiatric disorders often face difficulties in various social activities such as communicating with others, behaving out of the norm at work or at school, and living an isolated life. We are striving to research and develop pharmaceutical products that can help overcome these difficulties for patients by alleviating the various symptoms of psychiatric disorders. Alzheimer’s disease is also within our research scope for drug discovery.
We are also making efforts to search for better therapeutic medications for pain control. One of the major missions at Shionogi is to provide pharmaceutical products that demonstrate reliable effects quickly and safely for severe pain, a condition that can be difficult for other people to understand. We approach these issues by using innovative drug discovery technology, such as molecular imaging and gene editing.

Our latest collaboration

Project for drug discovery and medical research based on regeneration of synapses and neuronal functions (SK project)

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In 2018, the Shionogi-Kyoto University Joint Research Project (SK Project), which started in 2013, entered its second term (SK2).